Title: Biomimicry at the molecular level: Molecularly imprinted polymers as synthetic antibodies for biomedicine.
Speakers: Melissa Sedkaoui and Karsten Haupt
Date: 17/12/2020 at 14:00
Zoom link: https://univ-grenoble-alpes-fr.zoom.us/j/95592200584?pwd=KzRLK29UNW53bFd2Q3paVVlUZ2k4UT09
Meeting ID: 955 9220 0584 Passcode: 575324
Abstract
Molecularly imprinted polymers (MIPs) [1] are synthetic antibody mimics that specifically recognize molecular targets. They are highly cross-linked polymers synthesized in the presence of the target molecule (the ‘antigen’) or an epitope thereof, acting as a molecular template. This templating induces three-dimensional binding sites in the polymer, complementary to the template in size, shape and chemical functions. The synthetic antibody can recognize and bind its target with an affinity and selectivity on a par to biological antibodies. Herein, we demonstrate the potential of MIP nanogels of about 50 nm for bioanalysis, bioimaging and antibody therapy.[1] Haupt, K., Medina Rangel, P.X., Tse Sum Bui, B. Molecularly Imprinted Polymers: Antibody Mimics for Bioimaging and Therapy. Chem. Rev. 2020, 120, 9554-9582.